Careers | Vigene Biosciences

Careers

Careers at Vigene Biosciences, A Charles River Company

Headquartered in Rockville, Maryland, Vigene Biosciences, A Charles River Company, is a rapidly growing company that strives to be a leading manufacturer of viral vectors. We are proud to support researchers at any stage of development: from basic research, to animal studies, to clinical trials and commercialization. Our diverse customer base includes scientists all across the world from academia, government organizations, research institutes, biotechnology companies, and pharmaceutical companies.

We are passionate about our mission to help support scientists advance their biomedical research and ultimately to make gene therapy affordable and available to those in need. As we continue to grow, we are always looking for talented people to join our team who share our passion. We value our employees as important contributors to our mission, so we provide opportunities for career growth and encourage employees to develop new skills so they can grow with our company.

Equal Opportunity Employer

Vigene Biosciences, A Charles River Company, is an EEO/AA employer. Vigene Biosciences, Inc. is an equal employment opportunity employer and does not discriminate against any applicant on the basis of race, color, religion, sex, sexual orientation, gender expression and identity, national origin, ancestry, age, mental and physical disability, genetic information, any veteran status, military status or application for military service, or membership in any other category protected under applicable law. If you need reasonable accommodation for any part of the employment process, please contact us by email at jobs@vigenebio.com and let us know your request and contact information. Please note that only inquiries concerning a request for reasonable accommodation will be acknowledged from this email address. Requests for accommodation will be considered on a case by case basis.

Benefits

  • Healthcare benefits (Medical and Dental/Vision Insurance)
  • 100% Company Paid Life Insurance
  • 100% Company Paid Accident Insurance
  • Short and Long Term Disability Insurance
  • Paid Vacation, Floating Holidays and Sick Leave
  • 401(k) Plan with Safe Harbor Match
  • Employee Assistance Program
  • Dependent Care and Commuter/Transit FSA
  • Adoption Assistance
  • Education Assistance
  • Competitive Salary and Performance Bonus
  • Career development opportunities
  • Work-Life Balance
  • Fun, collaborative environment

Manufacturing Associate I, Plasmid Production

Job Title
Manufacturing Associate I, Plasmid Production
Location
Rockville,  MD 20850
Other Location
Description

DEPARTMENT: Plasmid Production

REPORTS TO: Manager, Facilities and Engineering

LOCATION: Rockville, MD (5-Research)

General Description

Vigene Biosciences has been a leader at the forefront of cell and gene therapy, Adeno-Associated virus or AAV vector production, adenovirus vector production, lentivirus vector production, retrovirus vector production, plasmid production, viral vector QC and analytical services, plasmid QC and analytical services, providing services and products to support this rapidly growing and increasingly important field.

As a member of plasmid manufacturing team, the Manufacturing Associate I applies a broad knowledge of biological, bioprocess, and mechanical principles to execute manufacturing protocols in a regulated and controlled environment. Performs in-process analysis of plasmid production.

Duties and Responsibilities

  • Perform basic upstream activities in seed train, bioreactor set up, fermentation monitoring, and harvest
  • Perform basic downstream activities such as cell lysis, chromatography, TFF, and final formulation steps
  • Perform in-process plasmid analysis
  • Document of all activities in Batch Records, Logbooks, Forms, etc. 
  • Follow verbal and written procedures in operating production equipment and performing processing steps accurately. Timely completion of appropriate production documentation
  • Exercise basic problem-solving skills and reporting observed process variances that deviate from normal operation to senior members of group in a timely manner
  • Participate as needed in process investigations to determine root cause and effect for process deviations
  • Monitor processes using automated production systems and controls under the guidance of manufacturing associate II or III
  • Prepare, sanitize, and disinfect equipment to prevent microbial contamination
  • Demonstrate ability to troubleshoot basic mechanical operations with input from senior manufacturing associates
  • Operate upstream/downstream process equipment, perform process methods, and prepare buffers with supervision
  • Ability to operate process equipment, perform laboratory procedures, data analysis, and complete documentation with training
  • Responsible for documenting in real time process steps in batch records/work instructions and submitting completed documents to Manufacturing Associate II/III for review.
  • Responsible for collecting and storage of in-process and final bulk product samples as per current manufacturing procedures
  • Perform daily tasks as per manufacturing schedule and communicating task status to Manufacturing Associate II/III
  • Perform other tasks as assigned that ensures sustainable right-first-time performance and satisfies client customers
  • Other responsibilities as needed

Qualifications for the Job

  • B.S. in Science or Engineering with < 1 year experience in a Biotech or related industry, or equivalent experience
  • Basic understanding of purification methods from cell culture processes 
  • Familiarity with the following: Upstream - bioreactors (Wave, BioFlo 120, XDR, and fermenters), Aseptically perform seed and fermenter inoculation, sampling and harvesting. Downstream - column chromatography (Affinity, IEX, HIC), buffer preparation, and Tangential Flow Filtration (TFF)
  • Able to work under supervision performing basic upstream and/or downstream tasks 
  • Detail oriented with strong organizational skills
  • Collaborate with Manufacturing Associate II on performance daily tasks. Responsible for the completion of daily tasks as per manufacturing schedule
  • Previous work in plasmid production desired but not required for position

Key Competencies

  • Demonstrates integrity and respect
  • Delivers results
  • Demonstrates business acumen
  • Fosters collaboration and teamwork
  • Champions change

Working Conditions

  • Flexible work hours – must be willing to work outside of normally-scheduled hours when needed
  • Standing, (sometimes prolong standing), sitting, pushing, pulling, walking, bending, stooping, and kneeling
  • Able to lift up to 35lbs.

Vigene Biosciences, Inc. is an equal employment opportunity employer and does not discriminate against any applicant based on race, color, religion, sex, sexual orientation, gender expression and identity, national origin, ancestry, age, mental and physical disability, genetic information, any veteran status, military status or application for military service, or membership in any other category protected under applicable law.

 

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